Beneficial rest through full-spectrum CBD tablets with melatoninview details

    Find a sense of calm with full-spectrum CBD tabletsview details

    Find relief with a topical CBD cream for at-home wellness to comfort and soothe muscles and joints. In two strengths- 100 mg and 300 mgview details

    Enjoy wellness through full-spectrum CBD tablets view details

    Find calming relief for mind and body with our full-spectrum CBD tincture oil in two strengths- 400mg and 800mgview details

    Elevate your bath experience with our CBD Bath bomb infused with eucalyptus essential oil. view details

    Elevate your bath experience with our CBD Bath bomb infused with lavender essential oil. view details

    Elevate your bath experience with our CBD Bath bomb infused with rose essential oil. view details

    Pharmaceutical-Grade Full-Spectrum Hemp CBD Melatonin Tablets
    Pharmaceutical-Grade CBD Full-Spectrum Hemp Myo-Inositol Tablets
    Relief Cream 300mg variant
    Pharmaceutical-Grade Full-Spectrum Hemp CBD Oral Tablets
    Tincture Oil 800mg variant
    Eucalyptus Bath Bomb
    Lavender Bath Bomb
    Tikva CBD Rose Bath Bomb

      Cannabis 101

        Our Blog
        This site is intended for U.S. healthcare professionals

        Providing patients with natural, pharmaceutical-grade solutions to our nation’s leading ailments.

        Tikva is unlike any other CBD brand on the market due to our pharmaceutical DNA. We set a new bar in the CBD industry by manufacturing our products to pharmaceutical standards with proprietary, indication-driven formulations.

        The Science Behind Tikva

        Quality raw materials

        GMP Manufacturing

        Analytics & Testing

        Pharmacokinetics

        Modes of administration

        Formulation Development

        Tikva Product Highlights

        THE SCIENCE BEHIND TIKVA

        Tikva has an exclusive partnership with Panaxia Pharmaceutical Industries – a world renowned Israeli Pharmaceutical company with over a decade of clinical research in medical cannabis. Thanks to their relentless emphasis on research and development, their entire group of companies, founded over 40 years ago, offers more than 600 medical products in over 30 international markets to treat a wide range of symptoms and conditions.

        Why does Tikva partner with an Israeli company to manufacture our products? It was an Israeli scientist, Dr. Raphael Mechoulam, who first discovered THC, CBD, and the entire endocannabinoid system in the 1960’s. Since then, Israel continues to lead the world in medical cannabis research and product development.

        Panaxia was the first company to be granted a license in 2009 by the Israeli Ministry of Health to conduct clinical research and make pharmaceutical cannabis products under stringent Good Manufacturing Practices (GMP) guidelines. This certification ensures and mandates that Panaxia products are manufactured under the most demanding requirements for validation and standardization.

        Most CBD companies only perform the required 3rd party test of their final products, but Panaxia takes it a step further and conducts three internal tests to guarantee safety and consistency throughout the entire manufacturing process. Tikva products are tested and subjected to stringent quality assurance protocols and pre-determined specifications required of pharmaceutical medicines.

        For over a decade, Panaxia has conducted numerous clinical trials on medicinal cannabis, including studies on migraines, kidney disease, psoriasis, and epilepsy. Due to federal restrictions, U.S. cannabis and hemp companies are just starting to do high-level research and studies on their products. Panaxia is already a decade ahead on product commercialization, clinical studies, and data collection, making Tikva products

        QUALITY RAW MATERIALS

        Pharmaceutical quality requirements must include the raw materials the end-product is made from. For Tikva, requiring rigorous pre-determined hemp specifications is a first and crucial step in maintaining quality.

        We commit to the highest standards of integrity to protect consumers, ensuring our products are safe and evaluated against specific and measurable quality attributes. Panaxia has a pharmaceutical grade standard for our raw materials that are far more stringent than current USDA requirements – Tikva’s hemp must pass multiple lab tests on profile, potency, heavy metals, microbiological contamination, mycotoxins, pesticides, and foreign matter.

        Not only do we conduct more testing than our competitors, but our specifications are also significantly more stringent to comply with pharmaceutical standards. For example, the USDA requires your total aerobic micro colony-forming units whereas our requirement for aerobic microbial count must be less than 10,000 colony-forming units.

        State mandatory testing requires one cannabinoid potency test to verify that the product doesn’t exceed THC federal levels. We perform multiple cannabinoid potency tests to gather statistically significant data for analysis of possible contaminants and ensure product safety.

        GMP MANUFACTURING

        The rules governing each industry may differ significantly; however, the main purpose of GMP is always to prevent harm from occurring to the end user.

        Additional tenets include ensuring the end product is free from contamination, manufacturing consistency, well-documented manufacturing, well-trained personnel, and quality checks throughout the manufacturing process — not just at the end phase. Even the primary and secondary packaging on all Tikva products is completed consistent with GMP requirements.

        Once we have tested the US grown hemp biomass to meet our predetermined quality specifications, CBD is extracted in a GMP cleanroom environment using non-volatile ethanol extraction – a safe extraction method that separates the CBD-rich oil and other beneficial minor cannabinoids and terpenes without harmful chemical residue.

        Pre-mixed excipients that are formulated to enhance stability, bioavailability and delivery are sent from Panaxia’s GMP central production facility in Israel directly to Panaxia’s site in the US and are mixed with the full-spectrum CBD extract. Panaxia then manufactures all Tikva products using their patented and proprietary processes and formulations.

        ANALYTICS & TESTING

        Panaxia’s Analytical Methods

        HPLC/UV – Panaxia retains state-of-the-art facilities and technologies and employs analytical methods and guidelines that are certified and meticulously referenced.

        Panaxia’s current analytical method uses HPLC/UV to identify and quantify: THC, THCA, CBD, CBDA, CBN, CBG, CBGA, CBC, and THCV. Their improved HPLC/UV analytical method reduces runtime while lowering costs. It also features an internal standard to improve monitoring for instrument performance.

        Panaxia’s latest LC/MS/MS systems can quantify cannabinoids in blood samples, enabling them to perform Pharmacokinetic (PK) studies faster and more cost-effectively. The system can also identify and quantify more cannabinoids, terpenes and degradation products, enhancing the ability to develop innovative products that can treat a wide range of medical indications.

        Tikva Product Testing

        Only after passing multiple internal tests and ensuring the product matches predetermined specifications are Tikva products sent to an ISO/ IEC 17025 accredited laboratory for mandatory microbial and potency testing. Though 3rd party testing is required for all CBD brands, ISO accredited laboratories are not.

        All Tikva products are lot-track-traced with a batch and lot number on the bottom of the carton. To ensure safety and consistency, each product includes a batch-specific Certificate of Analysis and accompanying QR code on the carton.

        PHARMACOKINETICS

        Sometimes described as “what the body does to a drug,” Pharmacokinetics refers to the movement of drug into, through, and out of the body – The time course of its absorption, bioavailability, distribution, metabolism, and excretion. Drug pharmacokinetics determines the onset, duration, and intensity of a drug's effect. (Le, 2022)

        The pharmacokinetics of phytocannabinoids includes a number of processes:

        • Absorption into the bloodstream in each mode of administration method.
        • The distribution of the absorbed cannabinoids to the body’s organs and tissues.
        • The metabolizing processes occurring in the liver and other parts of the body.
        • Elimination via feces, urine, sweat, oral fluids, and hair follicles.

        The administration method and formulation of a cannabis product are significant factors in determining the rate and extent of the absorption of the active ingredients into the bloodstream. Administration types greatly affect bioavailability by changing the number of biologic barriers a drug must cross or by changing the exposure of a drug to pumping and metabolic mechanisms (Stan K. Bardal et. al, 2011.

        Bioavailability is the proportion of a drug or other substance that enters the blood circulation when introduced into the body and so is able to have an active effect. It is essential for a medical product to have high bioavailability to ensure the API (active pharmaceutical ingredient, in this case CBD) achieves the desired goal and reaches the desired part of the body.

        Unlike other cannabis companies, Panaxia supports Tikva’s products with pharmacokinetic data to know how fast and how completely the API is absorbed into the body.

        MODES OF ADMINISTRATION

        One of the most important aspects of an effective medicine is the mode of administration. Each mode, or delivery method, has specific purposes, advantages, and disadvantages.

        Modes of administration include oral (tablets, capsules, chewables, liquids), injection, sublingual, rectal, vaginal, ocular, otic, nasal, topical, and inhalation.

        ORAL

        Oral administration is the most frequently used route of administration because of its simplicity, convenience, and safety.

        Absorption may begin in the mouth and stomach for drugs administered orally, however, most drugs are usually absorbed from the small intestine. The drug passes through the intestinal wall and travels to the liver before being transported via the bloodstream to its target site. The intestinal wall and liver chemically alter (metabolize) many drugs, decreasing the amount of drug reaching the bloodstream (Le, 2022)

        Consequently, bioavailability of drugs administered orally varies greatly. This route requires the drug or API to move through the digestive tract, greatly diminishing the efficacy of the drug. Because bioavailability and modes of administration make a significant impact on medicine, oral drugs are often given in smaller doses when injected intravenously to produce the same effect on the patient.

        Pharmaceutical medicines must have the proper excipients (an inactive and safe substance that serves as the vehicle or medium to enhance stability, bioavailability and delivery of the API) to ensure efficacy of the final product.


        TOPICAL

        Topical administration involves application of the drug primarily to elicit local effects at the site of application and to avoid systemic effects. Examples include drugs administered to the eye, the nasal mucosa, or the skin. Generally, drugs are formulated to be less lipophilic to reduce systemic absorption.

        Unless a topical cream has been specially formulated to penetrate the outer dermal layer of the skin, it will not reach the muscles to provide proper relief.


        SUBLINGUAL

        Sublingual (under the tongue) or buccal (between gum and cheek) administration is advantageous for drugs that have low oral availability because venous drainage from the mouth bypasses the liver. Drugs must be lipophilic to be absorbed rapidly. Buccal formulations can provide extended-release options to provide long-lasting effects (Stan K. Bardal et. al, 2011)

        The main advantage of sublingual administration is the high level of dosing control and the self-titration relative to inhalation administration and oral administration. Additional advantage of sublingual administration is that the active ingredients are absorbed directly into the bloodstream and do not go through the digestive system, such that they bypass the “first-pass effect” in the liver.

        FORMULATION DEVELOPMENT

        Pharmaceutical formulation development is a crucial step to determine the optimal dosage, composition, and process to achieve a manufacturable, chemically and physically stable throughout the manufacturing process and product shelf life, and bioavailable product. Also, many quality standards and special requirements must be met to ensure the product’s efficacy and safety.

        Panaxia currently holds seven patents on delivery methods and formulations.
        Proprietary analytical methods allow Panaxia’s R&D team to specify and standardize up to nine components in Tikva products. They also can identify and quantify eleven major and minor cannabinoids, including THC, THCA, CBD, CBDA, CBN, CBG, CBGA, CBC, THCV, delta-8-THC and 11-hydroxy-THC. Tikva products are always made from full-spectrum hemp extracts, not CBD isolates or broad-spectrum extracts.

        Our formulations maximize absorption and bioavailability, which leads to consistently increased efficacy. The main raw plant materials and formulation excipients were selected to synergistically facilitate the functioning of the dominant plant actives (CBD).

        Because Panaxia conducts these studies, they can ensure each Tikva delivery method effectively and efficiently delivers the CBD where and when needed. Tikva’s proprietary tablet formulations bypass the liver to avoid the first pass effect, maximizing absorption for optimal therapeutic potential. Tikva’s CBD creams are formulated to penetrate the outer dermal layer of the skin to deliver CBD deep into the muscles to provide fast-acting, localized relief. Tikva products are designed to be absorbed effectively, so we don’t need to hyper-concentrate our formulations. Highly bioavailable, lower-dosed products enable safe and effective dose titration, so your patients can feel confident while determining their optimal CBD dosage.

        A cannabis product may say it has a high concentration of CBD, but it could have very low bioavailability, making it less effective than a lower concentration product with high bioavailability. These types of products lead to dosing uncertainty and overuse.

        Instead of taking more and more milligrams of a CBD product that isn't being absorbed effectively into the body, your patients can take Tikva’s lower-dosed CBD specially made to maximize absorption so your patients can achieve maximum impact with less product!

        Along with Pharmacokinetic studies, Panaxia performs stability testing on all Tikva products to ensure safety and verify shelf-life duration. Stability testing provides evidence on how the quality of a drug substance or drug product varies with time under the influence of environmental factors such as temperature, humidity, and light, and to establish a re-test period and shelf-life. These tests are essential in traditional pharmaceuticals, and they should be applied to medical hemp and cannabis products as well.

        TIKVA PRODUCT HIGHLIGHTS

        Indication-driven, natural solutions manufactured to pharmaceutical standards

        CBD MELATONIN TABLETS

        Tikva wants to support your patients’ sleep hygiene with our pharmaceutical-grade, non-habit-forming sleep aid that combines two natural compounds - CBD and melatonin.

        Each tablet has 10mg of CBD and 3mg of melatonin, specially formulated to help your patients fall asleep, stay asleep, and wake up feeling refreshed. We recommend patients take one tablet with water 20 minutes before bedtime.

        Benefits of combining CBD and Melatonin

        While melatonin alone can help a patient fall asleep, the hormone only modulates the sleep/wake cycle, and does not facilitate sustained or restful sleep. Therefore, patients may not achieve relief with melatonin alone.

        Tikva’s precise ratio of CBD to melatonin and additional excipients work synergistically to ensure increased bioavailability and higher therapeutic value per dose.

        Each API has a unique dose to provide distinctive benefits related to sleep regulation and quality – The melatonin activates your patients’ sleep/wake cycle to help them go to sleep, while the CBD provides additional support to help your patient stay asleep throughout the night.


        CBD MYO-INOSITOL TABLETS

        Help your patients reduce stress, naturally, with Tikva’s CBD + Myo-inositol tablets – A one-of-a-kind daily supplement that combines the calming relief of CBD with the clinically proven benefits of myo-inositol in one convenient tablet.

        Each tablet contains 10mg of CBD and 100mg of myo-inositol. Patients can take one to three tablets, daily. We recommend patient take supplement for at least one week before determining optimal results.

        Benefits of combining CBD and Melatonin

        While melatonin alone can help a patient fall asleep, the hormone only modulates the sleep/wake cycle, and does not facilitate sustained or restful sleep. Therefore, patients may not achieve relief with melatonin alone.


        CBD ORAL TABLETS

        Help your patients reduce stress, naturally, with Tikva’s CBD + Myo-inositol tablets – A one-of-a-kind daily supplement that combines the calming relief of CBD with the clinically proven benefits of myo-inositol in one convenient tablet.

        Each tablet contains 10mg of CBD and 100mg of myo-inositol. Patients can take one to three tablets, daily. We recommend patient take supplement for at least one week before determining optimal results.

        Benefits of combining CBD Oral Tablets

        While melatonin alone can help a patient fall asleep, the hormone only modulates the sleep/wake cycle, and does not facilitate sustained or restful sleep. Therefore, patients may not achieve relief with melatonin alone.


        CBD RELIEF CREAM

        Help your patients reduce stress, naturally, with Tikva’s CBD + Myo-inositol tablets – A one-of-a-kind daily supplement that combines the calming relief of CBD with the clinically proven benefits of myo-inositol in one convenient tablet.

        Each tablet contains 10mg of CBD and 100mg of myo-inositol. Patients can take one to three tablets, daily. We recommend patient take supplement for at least one week before determining optimal results.

        Benefits of combining CBD with menthol, camphor, and capsicum

        While melatonin alone can help a patient fall asleep, the hormone only modulates the sleep/wake cycle, and does not facilitate sustained or restful sleep. Therefore, patients may not achieve relief with melatonin alone.


        CBD TINCTURE OIL

        Help your patients reduce stress, naturally, with Tikva’s CBD + Myo-inositol tablets – A one-of-a-kind daily supplement that combines the calming relief of CBD with the clinically proven benefits of myo-inositol in one convenient tablet.

        Each tablet contains 10mg of CBD and 100mg of myo-inositol. Patients can take one to three tablets, daily. We recommend patient take supplement for at least one week before determining optimal results.

        Benefits of combining CBD Tincture Oils/strong>

        While melatonin alone can help a patient fall asleep, the hormone only modulates the sleep/wake cycle, and does not facilitate sustained or restful sleep. Therefore, patients may not achieve relief with melatonin alone.

        Tikva’s precise ratio of CBD to melatonin and additional excipients work synergistically to ensure increased bioavailability and higher therapeutic value per dose.

        Each API has a unique dose to provide distinctive benefits related to sleep regulation and quality – The melatonin activates your patients’ sleep/wake cycle to help them go to sleep, while the CBD provides additional support to help your patient stay asleep throughout the night.

        HAVE MORE QUESTIONS?

        Are you a healthcare practitioner? Get in touch with our service team, powered by PharmaCentra Physician Support!

        Available weekdays: xx-xx
        Phone: 833-30-TIKVA (833-308-4582)
        Email: TIKVA@physician-reach.com